Your kidneys are basically your blood’s filtration system.

This means that any toxins that are in your blood ultimately finds their way into your kidneys, where they are later transformed and expelled through urine. All of your blood is filtered by these organs multiple times a day.

Kidney disease and failure are so hard to detect, in fact, that it’s possible to lose up to 90% of kidney function without experiencing any symptoms or problems.

Drug-induced kidney damage

Drugs are one of the most common causes of kidney damage. Over the last 30 years, cases of drug-induced acute kidney injury have been on the rise.

According to a 2008 review published in American Family Physician, drugs cause approximately 20% of community and hospital-acquired episodes of acute renal failure. Among older adults, the incidence of drug-induced nephrotoxicity may be as high as 66%.

In part, drugs can cause kidney inflammation, which can lead to fibrosis and renal scarring, and thus, kidney failure.

Nephrotoxic drugs that cause kidney damage

Before taking any of these drugs, be aware that they are known to cause severe (and sometimes deadly) kidney damage.

If you already have kidney problems, these drugs can be deadly even in small doses. And so, make sure to only take medication prescribed by your healthcare provider and respect the recommended dose.

1.Antibiotics that include ciprofloxacin, methicillin, vancomycin, sulfonamides.

2.Analgesics, including acetaminophen and non-steroidal anti-inflammatory drugs (NSAID): aspirin, ibuprofen, naproxen, and others available only by prescription.

3.COX-2 Inhibitors including: celecoxib (Celebrex), rofecoxib (Vioxx), and valdecoxib (Bextra).

4.Heartburn drugs including proton pump inhibitor class. They include omeprazole (Prilosec), lansoprazole (Prevacid), pantoprazole (Protonix), rabeprazole (Rabecid, Aciphex), esomeprazole (Nexium, Esotrex).

5.Antiviral drugs, including acyclovir (Zovirax), used to treat herpes infections, and indinavir and tenofovir, both of them used to treat HIV.

6.High blood pressure drugs, including captopril (Capoten), lisinopril, ramipril, and angiotensin receptor blockers like candesartan and valsartan.

7.Rheumatoid arthritis drugs, including infliximab (Remicade); chloroquine and hydroxychloroquine, used to treat malaria and systemic lupus erythematosus as well as rheumatoid arthritis.

8.Lithium used to treat bipolar disorder.

9.Anticonvulsants, including phenytoin (Dilantin) and trimethadione (Tridione), used to treat seizures, as well as other conditions.

10.Chemotherapy drugs, including interferons, pamidronate, cisplatin, carboplatin, cyclosporine, tacrolimus, quinine, mitomycin C, bevacizumab, bevacizumab, cisplatin, and methotrexate.

Bonus: Alcohol – Alcoholics have a high risk of developing both kidney and liver failure, so enjoy a drink in moderation or forgot it completely. Chemicals including insecticides, herbicides, and ethylene glycol can also cause acute kidney injury.

Other risks

Acute kidney failure can lead to unpleasant problems including:

  • Shortness of breath, caused by fluid buildup in the lungs
  • Chest pain, caused by inflammation of the lining that covers your heart (pericardium)
  • Muscle weakness caused by electrolyte imbalance
  • Permanent kidney damage, requiring either permanent dialysis or kidney transplant for survival
  • Death

Other organs are also affected by prescriptions, including your liver, which detoxifies chemicals and metabolizes drugs.